David Cameron has said the Malaysian Airlines crash in east Ukraine is a "defining moment" for Russia.
Some 298 people died, including 10 Britons, when the plane crashed in a rebel-held area last week.
Pro-Russia separatists have been blamed for downing the jet, reportedly with a missile.
The PM said it was unlikely the plane was shot down deliberately - but warned of "hard-hitting" sanctions if Moscow did not change course on Ukraine.
'Clear choice'Mr Cameron said there was "anger" at what had happened and urged Moscow to halt supplies of weapons to the separatists, calling for "proper, long-term relationships" between Russia, Ukraine and the European Union.
He called for "unfettered access" to the crash site for international investigators and for bodies to be repatriated.
Addressing MPs in the Commons, Mr Cameron said "a conflict that could have been curtailed by Moscow, has instead been fermented by Moscow".
Relatives of some of the British victims have called for their bodies to be brought home.
The UK is set to push for increased sanctions against Russia at a meeting of EU foreign ministers on Tuesday.
Mr Cameron said the evidence pointed to the jet being downed by pro-Russian separatists.
He said: "President Putin faces a clear choice in how he decides to respond to this appalling tragedy. I hope he will use this moment to find a path out of this festering and dangerous crisis by ending Russia's support for the separatists.
"If he does not change his approach to Ukraine in this then Europe and the West must fundamentally change our approach to Russia.
"Those of us in Europe should not need to be reminded of the consequences of turning a blind eye when big countries bully smaller countries."
PM: Crash Russia's 'defining moment'
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